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Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 23-35

Possible pharmacological and nonpharmacological treatments for diabetic polyneuropathy

Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan

Correspondence Address:
Dr. Sidra Munir
Islamia College Peshawar, Peshawar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mtsp.mtsp_2_21

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Objective: Diabetic neuropathy (DN) is a microvascular complication of diabetes that arises due to damage to nerves. It arises due to hyperglycemia and the pathways that it follows are most commonly initiated by reactive oxygen species-induced oxidative stress. Methodology: There are various growth factors and receptors involved in the process, and the usual understanding of its origin is rather unclear. Until now, no absolute cure exists for the treatment of DN; however, there are a lot of pharmacological and nonpharmacological treatment options that are recommended and can help to ease the pain associated with DN. This paper reviews these options that are divided into broad categories of pharmacological and nonpharmacological treatment options. Results: The pharmacological treatment options include the use of natural plants with antioxidant and anti-inflammatory potential, thymosin, Pregabalin, duloxetine, anticonvulsants, and antinociceptive agents. Conclusions: Whereas, the nonpharmacological treatments suggest the surgery, supplements, acupuncture, exercises such as yoga, and transcutaneous electrical nerve stimulation therapy. Both of these can help patients, especially if consider collectively.

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